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Mirez 7.5mg Tablet 1 Strip
Mirez Tablets are prescribed for the treatment of Major Depressive Disorder (MDD)
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✅ Description:
Pharmacodynamics:
- The exact mechanism is unknown, but Mirtazapine enhances noradrenergic and serotonergic activity.
- It acts as an α2-adrenergic receptor antagonist, leading to increased neurotransmitter release.
- It blocks 5-HT2 and 5-HT3 receptors, contributing to its antidepressant effects.
- Its H1 receptor antagonism explains its sedative properties.
- Moderate α1-adrenergic and muscarinic antagonism may cause orthostatic hypotension but results in fewer anticholinergic side effects.
Pharmacokinetics:
- Rapidly absorbed after oral administration, reaching peak levels in ~2 hours.
- 85% plasma protein binding.
- Elimination half-life: 20-40 hours (26 hours in males, 37 hours in females).
- Metabolized via demethylation, oxidation, and conjugation, excreted through urine and feces.
Safety Advices
Alcohol
UNSAFE
- Avoid alcohol while taking Mirtaz 7.5 Tablet.
- Risk: Increased drowsiness, dizziness, and impaired cognitive function.
Pregnancy
UNSAFE
- Use during pregnancy is not recommended unless necessary.
- Risk: Animal studies show harmful effects on fetal development.
- The doctor will assess the benefit vs. risk before prescribing.
Breastfeeding
UNSAFE
- Possibly unsafe during breastfeeding.
- Risk: The drug may pass into breast milk and affect the baby’s behavior and growth.
- Infants should be monitored for any side effects or developmental issues.
Driving
CAUTION
- Risk: May cause drowsiness, dizziness, impaired concentration, and alertness.
- Advice: Avoid driving or operating machinery if affected.
Kidney
CAUTION
- Use with caution in patients with kidney disease.
- Dose adjustment may be required based on renal function.
- Consult a doctor for appropriate dosing.
Liver
CAUTION
- Use with caution in patients with liver disease.
- Risk: Liver impairment may affect drug metabolism.
- Dose adjustment may be required—consult your doctor.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Depression
✔️ Quick Suggestions:
- Mirtaz 7.5 Tablet starts to work more quickly than other antidepressants.
- Avoid driving or operating dangerous machinery as it may decrease alertness.
- Avoid consuming alcohol when taking the Mirtaz 7.5 Tablet, as it may cause excessive drowsiness and calmness.
- If your doctor asks you to stop Mirtaz 7.5 Tablet, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
- Notify your doctor immediately if you develop a sore throat or fever or stomatitis during treatment with Mirtaz 7.5 Tablet.
- Mirtaz 7.5 Tablet starts to work more quickly than other antidepressants.
✔️ Dosage & Administration
Adults:
- Starting dose: 15 mg/day (preferably in the evening or before sleep).
- Effective dose range: 15-45 mg/day.
- Dose adjustments: Increase if needed, up to a maximum of 45 mg/day, with changes at 1-2 week intervals.
Children: Not recommended.
Missed Dose:
- Take as soon as remembered unless it's near the next scheduled dose.
- Do not take a double dose to compensate for a missed one.
👉 Use only as directed by a registered physician.
✔️ Side Effects
- Common: Dizziness, drowsiness, dry mouth, increased appetite, weight gain.
- Serious (Rare): Agranulocytosis (low white blood cell count), abnormal liver function tests.
✔️ Drug Interactions
⚠️ Avoid concomitant use with:
- Monoamine Oxidase Inhibitors (MAOIs) (Risk of severe reactions).
- Serotonergic drugs (e.g., SSRIs, SNRIs, St. John’s Wort, tramadol) – Risk of serotonin syndrome.
- Carbamazepine, Phenytoin, Cimetidine (May affect drug metabolism).
- Alcohol & Diazepam (May increase sedation).
✔️ Contraindications
- Hypersensitivity to Mirtazapine or any excipients.
- Concurrent use with MAOIs or within 14 days of starting/stopping an MAOI.
✔️ Precautions & Warnings
- Monitor for worsening depression, suicidal thoughts, or unusual behavioral changes.
- May cause agranulocytosis—seek medical help if fever, sore throat, or signs of infection occur.
- Can impair judgment and motor skills due to sedation.
- May cause orthostatic hypotension (dizziness upon standing).
- Liver enzyme ALT (SGPT) elevation may occur.
✔️ Use in Pregnancy & Lactation
- Pregnancy Category C – Use only if benefits outweigh risks.
- Caution is advised if breastfeeding.
✔️ Storage Conditions
- Store below 30°C, away from light and moisture.
- Keep out of reach of children
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
