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Mirez 7.5mg Tablet 1 Strip
Mirez Tablets are prescribed for the treatment of Major Depressive Disorder (MDD)
📄Prescription Required
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Price: ৳ 63
MRP:
৳
65
3%
Off
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Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
Pharmacodynamics:
- The exact mechanism is unknown, but Mirtazapine enhances noradrenergic and serotonergic activity.
- It acts as an α2-adrenergic receptor antagonist, leading to increased neurotransmitter release.
- It blocks 5-HT2 and 5-HT3 receptors, contributing to its antidepressant effects.
- Its H1 receptor antagonism explains its sedative properties.
- Moderate α1-adrenergic and muscarinic antagonism may cause orthostatic hypotension but results in fewer anticholinergic side effects.
Pharmacokinetics:
- Rapidly absorbed after oral administration, reaching peak levels in ~2 hours.
- 85% plasma protein binding.
- Elimination half-life: 20-40 hours (26 hours in males, 37 hours in females).
- Metabolized via demethylation, oxidation, and conjugation, excreted through urine and feces.
Safety Advices
Alcohol
UNSAFE
- Avoid alcohol while taking Mirtaz 7.5 Tablet.
- Risk: Increased drowsiness, dizziness, and impaired cognitive function.
Pregnancy
UNSAFE
- Use during pregnancy is not recommended unless necessary.
- Risk: Animal studies show harmful effects on fetal development.
- The doctor will assess the benefit vs. risk before prescribing.
Breastfeeding
UNSAFE
- Possibly unsafe during breastfeeding.
- Risk: The drug may pass into breast milk and affect the baby’s behavior and growth.
- Infants should be monitored for any side effects or developmental issues.
Driving
CAUTION
- Risk: May cause drowsiness, dizziness, impaired concentration, and alertness.
- Advice: Avoid driving or operating machinery if affected.
Kidney
CAUTION
- Use with caution in patients with kidney disease.
- Dose adjustment may be required based on renal function.
- Consult a doctor for appropriate dosing.
Liver
CAUTION
- Use with caution in patients with liver disease.
- Risk: Liver impairment may affect drug metabolism.
- Dose adjustment may be required—consult your doctor.
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✔️ Uses
- Depression
✔️ Quick Suggestions:
- Mirtaz 7.5 Tablet starts to work more quickly than other antidepressants.
- Avoid driving or operating dangerous machinery as it may decrease alertness.
- Avoid consuming alcohol when taking the Mirtaz 7.5 Tablet, as it may cause excessive drowsiness and calmness.
- If your doctor asks you to stop Mirtaz 7.5 Tablet, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
- Notify your doctor immediately if you develop a sore throat or fever or stomatitis during treatment with Mirtaz 7.5 Tablet.
- Mirtaz 7.5 Tablet starts to work more quickly than other antidepressants.
✔️ Dosage & Administration
Adults:
- Starting dose: 15 mg/day (preferably in the evening or before sleep).
- Effective dose range: 15-45 mg/day.
- Dose adjustments: Increase if needed, up to a maximum of 45 mg/day, with changes at 1-2 week intervals.
Children: Not recommended.
Missed Dose:
- Take as soon as remembered unless it's near the next scheduled dose.
- Do not take a double dose to compensate for a missed one.
👉 Use only as directed by a registered physician.
✔️ Side Effects
- Common: Dizziness, drowsiness, dry mouth, increased appetite, weight gain.
- Serious (Rare): Agranulocytosis (low white blood cell count), abnormal liver function tests.
✔️ Drug Interactions
⚠️ Avoid concomitant use with:
- Monoamine Oxidase Inhibitors (MAOIs) (Risk of severe reactions).
- Serotonergic drugs (e.g., SSRIs, SNRIs, St. John’s Wort, tramadol) – Risk of serotonin syndrome.
- Carbamazepine, Phenytoin, Cimetidine (May affect drug metabolism).
- Alcohol & Diazepam (May increase sedation).
✔️ Contraindications
- Hypersensitivity to Mirtazapine or any excipients.
- Concurrent use with MAOIs or within 14 days of starting/stopping an MAOI.
✔️ Precautions & Warnings
- Monitor for worsening depression, suicidal thoughts, or unusual behavioral changes.
- May cause agranulocytosis—seek medical help if fever, sore throat, or signs of infection occur.
- Can impair judgment and motor skills due to sedation.
- May cause orthostatic hypotension (dizziness upon standing).
- Liver enzyme ALT (SGPT) elevation may occur.
✔️ Use in Pregnancy & Lactation
- Pregnancy Category C – Use only if benefits outweigh risks.
- Caution is advised if breastfeeding.
✔️ Storage Conditions
- Store below 30°C, away from light and moisture.
- Keep out of reach of children
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Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
